Authors Statistics from 3 Countries
| Country | Count of Articles |
|---|---|
| United States | 2 |
| China | 1 |
| Indonesia | 8 |
Articles
Computational drug repositioning using big data from genetic studies
Abstract
This mini-review gives the development of computational drug repositioning using big data from perspective of genetic study. The reverse profile principle is utilized to reposition drug hits by investigating gene expression, genotyping and GWAS data. Several big data sets are introduced, which are remarkable references that utilized for the genetic studies. Relevant computational genetics methods and the developments are briefly described as well. This review aims to give insights into this area so as to raise more ideas as well as to attract more attentions for this ascendant field. With the development of information technology and engineering applications, prosperous results are highly expected.
Read full articleNovel kit for efficient extraction of long-segment genomic DNA by nanodisk adsorption
Abstract
The acquisition of complete DNA is usually the first and most critical step in many basic molecular biology applications. Isolation of complete total DNA from tissue samples is related to different physical and biochemical properties of tissue. Long fragments of DNA are easily degraded and fragmented, which poses a challenge for extracting complete long fragments of DNA. By comparing several different extraction methods and verifying the concentration and length of extracted DNA, it is proved that the kit we used has high efficacy. We provide tissue kit DNA extraction for long fragments and obtain long fragments of high purity DNA from almost any type of tissue, especially muscle and blood tissues.
Read full articleMarketing Research : The Application of Auto Sales Forecasting Software to Optimize Product Marketing Strategies
Abstract
The aims of this study is to apply the Auto Sales Forecasting software to predict sales transaction data. The Auto Sales Forecasting software consists of two main features namely descriptive analysis and forcasting features along with its visualization. Forecasting methods contained in the Auto Sales Forecasting application are forecasting methods of Simple Moving Average, Robust Exponantial Smoothing, Auto ARIMA, Artificial Neural Network, Holt-Winters, and Hybrid Forecast. The Auto Sales Forecasting software can intelligently choose the best forecasting method based on RMSE values. The results showed that the Auto Sales Forecasting software successfully analyzed the sales transaction data. From the analysis it was found that there were 43 types of products produced and sold by the Futry Bakery & Cake Store. Three of them are the types of products that are most in demand by consumers, namely Sweet Bread, Maros Bread, and Traditional Cakes 3500. The best selling product type, Sweet Bread, is used to build forecasting models. The best forecasting method is the Robust Exponential Smoothing method with the smallest RMSE value of 0.83 on the variable number of sold out products. Forecasting results using the Robust Exponantial Smoothing method show that the average number of products to sell for the next seven days ranges from 116 products with a certain confidence interval value.
Read full articleInvestigation on the effect of cold drawing process on mechanical properties and structure of seamless steel (Ck60) tube
Abstract
The cold drawing process is one of the precise metal forming techniques which have attracted attention by many researchers with respect to the given properties such as potential for improvement of mechanical properties of the material, achieving of accurate dimensional tolerances and rise of quality at final surface so that different studies are conducted on properties of various materials in the course of analysis of its effect. Using cold drawing and also exertion of special heat treatment cycle in this investigation, initially the seamless steel tube Ck60 has been produced and then effect of cold drawing has been assessed on the mechanical properties and structure of steel. The production process of seamless steel tube includes two phases of cold drawing which was followed by surface reduction levels 15.1% and 13.7% respectively. In order to analyze mechanical properties, tensile test and hardness-testing was used and metallography test was also employed to observe the structure. The given results indicate that the seamless steel tube Ck60 produced by means of this production process has ultimate tensile strength (1021 MPa), yield strength (950 MPa) and elongation (9%). Moreover, the value of hardness mean was 312 for the final tube in Vickers Hardness Test. The images taken from optical microscopy also show that the final structure of tube is uniform and as perlite ferrite.
Read full articleComparative Analysis of Plate Girder Designs In The Composite Bridge Between AASHTO LRFD Bridge Design Specifications 2017 Regulation with SNI 1729: 2015
Abstract
In the world of construction there are various methods and types of materials used to support the passage of a construction work. One of them is composite girder plate. Composite girder plate is one of the many construction methods that combine two construction materials that are physically different in nature, namely concrete with steel. This type of composite girder plate construction is commonly used for bridge construction work with a fairly large span and width. In its use, of course, it must be preceded by stages of careful planning on a standard and valid basis as well. In the following research will discuss and look for similarities and differences regarding the two types of rules in the planning of composite girder plates, namely the rules of planning composite girder plates using AASHTO LRFD BRIDGE DESIGN SPECIFICATIONS 2017 with SNI 1729: 2015. After doing the initial stages of modeling using CSI Bridge software using the profile cross section constraints of the AASHTO provisions, the internal force obtained is Moment Force (Mu) of 3469.13 kNm and Shear Force (Vu) of 225.98 kNm. Then proceed with the analysis of calculations with the help of Microsoft Excel software namely calculating using the AASHTO LRFD BRIDGE DESIGN SPECIFICATIONS 2017 regulations for stability requirements of strong boundary conditions on the bending requirements. Then a Nominal Moment (ØMn) value of 6420.19 kNm is obtained. Then proceed to calculate the same planning constraints, but this time using SNI 1729: 2015 regulations. Obtained Nominal Moment Value (ØMn) of 6579.88 kNm. Then it can be concluded that the two regulations produce a safe and strong planning, of course in accordance with applicable regulations namely: Moment (Mu <ØMn).
Read full articleInfluence of Conditions on Early Warning in Lowering Levels of Infant Mortality and Health Disorders
Abstract
The process of the development of the world of digital technology has affected many areas. One of the central areas experiences penetration of digitization technology is in the area of health. One of the influences that add to the health field is medium with a large number of emerging health applications that can be easily accessed via a smartphone or tablet device. For example, in developed countries currently, examination process health the ear or hearing children have can be done using your smartphone. Through this tool, the doctor can diagnose the infection and prepare the proper treatment for patients. Growing number of mobile applications in the health field will certainly ease the course of patient care. There are currently a lot of digital health applications. For that we researchers designed a program shaped application that can be run over the web and sms gateway, to monitor the health conditions of babies from a variety of disorders. The information disseminated through the web and sms gateway can be accessed easily by the mothers who are nurturing her baby, so that a mother will get the right information on how to care for a baby with healthy and avoid distractions endanger the health of infants. this application may be applied in health centers, posyandu, or hospital.
Read full articleComparative Analysis Study Of ATC-40 and SNI 1726-2012 Guidelines for Beam Structure Performance and Column Trans Studio Apartments Applications Using Dynamic Response Spectrum Analysis Methods
Abstract
The earthquake that often hit Indonesia caused thousands of lives and caused damage to buildings. These earthquakes often occur because Indonesia is in two regions, namely the Pacific earthquake path (Circum Pacific Earthquake Belt) and the Asian earthquake lane (Trans Asiatic Earthquake Belt). Earthquake disasters cause damage to building structures. When an earthquake occurs, it is expected that the building can accept earthquake force at a certain level without significant damage to its structure. In general, earthquake analysis is divided into two major parts, namely static earthquake analysis and dynamic earthquake analysis. In buildings that are very high, irregular, multilevel, and buildings that require enormous accuracy are used dynamic analysis planning, which consists of a variety of spectral response analysis and dynamic time response dynamic analysis. This study aims to determine the building's security in terms of displacement, drift, and base shear. The method used is a dynamic analysis of the response spectrum using the ETABS program. The maximum total drift in the X direction is 0.0200475 m and in the Y direction is 0.020405 m, so the building is safe against ultimate boundary performance (0.02h) and service boundary performance {(0.03 / R) x h}. So that the displacement in the building does not exceed the maximum displacement, the building is safe from earthquake plans.
Read full articleEvaluation Study of Kedunglarangan River To Protect Flood In Pasuruan and Sidoarjo
Abstract
Construction of the Kedunglarangan river flood control system designed to prevent flooding every rainy season in the Bangil sub-district. Kedunglarangan River is a river that flows in two regencies Sidoarjo and Pasuruan which has an area of 282.67 km2 watershed with a river length of 23.7 km. Kedunglarangan river has 4 (four) watershed sub-systems. The scope of this flood prevention work-study is the normalization of the Kedunglarangan River starting from the meeting with the Wrati River downstream up to 7 km. Normalization work is carried out with excavation and river widening to meet flood discharge in accordance with the conditions of the study area. If the river excavation work is done in accordance with the design master will form a basin that causes the creation of a dike. In this condition, it will be a temporary water reservoir where the water velocity is very low. So the work carried out the impact is only temporary. From the results of analysts, it is more efficient to do river widening and embankment raising rather than increasing river depth. River excavation work like that is very risky to create very fast sedimentation. Normalization method with river widening is one way to maintain the river flow downstream and flood water levels
Read full articleComparative Analysis Method of Work, Time and Cost of Concrete Spun Pile Work with Bored Pile On Construction of the Light Rail Transit (LRT)
Abstract
Building construction consists of two parts, namely the upper building and lower building. The upper building transmits forces to the lower building, which then from the lower building is channeled to the supporting soil. Pile foundation is a part of the lower structure that is used to receive and distribute the load from the upper structure to the supporting soil which is located at a certain depth determined by the results of the soil investigation. Piles are used as building foundations if the soil under the building base does not have enough bearing capacity to carry the weight of the building working on it. The stake used in this comparison is the Concrete Spun Pile and Bored Pile foundation. The results of the study show that the Bored pile method is slightly more complicated than the Concrete spun pile method. In terms of time required for the Concrete spun work is 6 hours, while for Bored piles per point is 9 hours assuming the work is 3 months In terms of the cost of foundation work of 1000mm diameter and 30m depth using the Concrete spun pile method is Rp. 13,704,241,634.10 for 156 points. whereas for the Bored pile method with a diameter of 1200mm and a depth of 30m is Rp. 14,242,797,932.85 for 78 points. So the foundation work with the Concrete spun pile method is more effective and efficient than the Bored pile method based on the method of implementation, time and cost.
Read full articleAnalysis of Drainage Capacity in Cimanggis Hill Clove II Housing Area Depok City
Abstract
Generally, Drainage could be defined as technical measures to reduce excessive water, either from rainwater, permeation, or excessive irrigation water from a region, therefore the land function not disrupted. The purpose of this study are to analyze, learn and evaluate the drain condition and capacity in the Bukit Cengkeh II Residential, Cimanggis Sub-district, Depok City specifically in blockhouse G, H and I to the flood discharge that occurred. The data and information used for this study are primary data (personal research data collected by the author) and secondary data (rainfall from BMKG and nearest Irrigation Center). Flood discharge study methods use two methods, i.e. Rational method and Hasper's method. From these two methods, we used the largest volume of the flood discharge. The results of the Flood discharge planning in block G are 2,39 m3/sec, block H are 5,42 m3/sec, and block I 1,12 m3/sec. There found 10 drains identified as runoff or unsecured. The alternative solutions to runoff or unsecured drains problems are create a new drains dimension plan or construct an infiltration well.
Read full articleImprovement of Biology Learning Results Through the Application of Problem-Based Instruction Approach Oriented Think Pair Share Learning Model
Abstract
This research is a Classroom Action Research with the application of Problem Based Instruction approach oriented Think Think Share learning models in the learning process. The subjects of this study were 40th-grade students of SMP Negeri 40 Makassar in the first semester of the 2018/2019 school year. The implementation of this research consisted of two cycles. The data collected was analyzed descriptively. Based on the results of the study note that in the first cycle has not reached the expected standard classical limitations, this can be seen from the final value which only reached an average of 61.50 with a percentage of completeness of 65%. While in the second cycle the final grades of students have increased. This can be seen with the increase in the average value of student learning outcomes which reached 73.50 with a percentage of completeness of 80%. Based on the results it can be concluded that the application of the Problem Based Instruction approach oriented to Think Pair Share learning models can improve learning outcomes in biology subjects in the eighth grade at SMP Negeri 40 Makassar
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